A utophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure.

Here we demonstrate that Ä9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy.

Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2á (eIF2á) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis.

We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo.

These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.

Abstract in PDF here: On a mission from God!

Please also read: Long Term Exposure To Cannabis

Ed Note: We knew this since 1974 and now we've been waiting for 35 years for this!

How many people have died since 1974, that we could have saved?

Why has it taken so long for science to break through ideology?

Meanwhile, cigarettes are completely legal you can light up anywhere even when close to little children and cigarettes kill in excess of 38,000 Americans every year from passive smoke inhalation ( and believe me 38,000 is an awful lot of dead bodies from people who did not even enjoy the habit ...) Yet marijuana has killed no-one (because its toxicity is zero) and studies have shown that in a population with marijuana smokers, these are the same people who have a lower incidence of cancer than non-smokers overall, including lung cancer.